Dr. Moris Silber in the lab during initial Rugenix trials
Rugenix is known for its effectiveness and use for oral supplementation in order to rapidly increase in skeletal muscle growth, strength, power output, and as anti-fatigue in elite athletes (Olympic and Professional), as well as for fitness in general population. Read on below to learn more about how and why Rugenix is so powerful.
The link between the alpha-ketoglutaric acid metabolic cycle and catabolic conditions in actively contracting skeletal muscle has been known since the early 1990’s. The particular role of dietary supplemented glutamine and its natural derivatives in arresting the process of muscle protein waste caused by stress has been epitomized (Wusteman et al., 1995; Vaubourdolle et al.,1991; Roth et al., 1990; Furst et al., 1990). These observations have also highlighted to the unique biological properties of glutamine, compared to other amino acids, i.e., its abundance in the body (plasma, skeletal muscle, liver, kidney, intestines), its intra-cellular presence in quantitative amounts, its role in the reactions of nitrogen and carbon transport among tissues, and its importance as a primary oxidative fuel in rapidly dividing intestinal and stimulated lymphocytes, as well as oxidative fuel and essential structural element for growing (undergoing hypertrophy) cells. Glutamine administered to human subjects as amino bio-heterodimer Glycylglutamine resulted in rapid and significant increase in the arterial concentration of glycine and glutamine, with less than 1 % of the infused amino-heterodimer recovered into urine.
Futhermore, Alanyl-Glutamin, Alanyl alpha-Ketoglutarate, and Ornithine alpha-Ketoglutarate have been shown to moderate consistently the degree of negative nitrogen balance, effectively increased the intramuscular concentration of free glutamine, and maintained the concentration of the ribosomes in skeletal muscle in distressed (hypercatabolic) patients. It was concluded then that feeding amino acid glutamine or its derivative alpha-ketoglutarate as C-terminal located residue in an amino bio-heterodimer, results in increased protein synthesis in the body (Lochs and Hubl, 1990). In other clinical studies it was shown that glutamine and its derivatives do elevate plasma glutamine without changing the ammonia concentration gradient (Shils, 1994).
Creatine is another natural amino acid derivative in the body with superior anabolic impact on skeletal muscle metabolism and of other organs and tissues whose viability under any extreme catabolic stress conditions had acquired the most popularity in sports practice for its unique promoting effect on protein synthesis in growing muscle cells (Silber, 1998; Silber et al., 1975; lngwall et al.,1972) which actually reflects the activation of the transcribed and translated determinants for natural and safe skeletal muscle growth, strength, and power generation (Silber, 1998; Kreider et al., 1998; Odland et al., 1997; Greenhaff et al., 1993; Harris et al., 1992). As a nutrition supplement, Creatine is currently available in the monohydrate form combined after HPLC. This form, when used in elevated doses, higher than 2 g per day, often causes adverse reaction in the digestive tract, which considerably reduces the expected benefits from its absorbance.
Lately, an extended list of amino bio-dimers, trimers, and oligomers have been reported for their increased tolerance, solubility, and stability during ingestion, compared to their free amino acid constituents (Shils, 1994; Abidi, 1987). Also, amino bio-heterotrimers of Ornithine conjugated with alpha-Ketoglutarate have been shown to produce anabolic and performance enhancing effects in animal and human trials (Raul et al., 1995; Hatfield, 1994; Vaubordolle. et al., 1991). Relying on this evidence Dr. Moris Silber firstly claimed that Creatine alpha-Ketoglutarate can be produced via chemical organic synthesis and have the following molecular structure. Secondly, he claimed that the newly configured product of Creatine alpha-Ketoglutarate will demonstrate superior biological activity and physiological effects on skeletal muscle growth, strength, and power generation capacity, compared with its individual constituents, Creatine and alpha-Ketoglutaric acid, in elite force/velocity athletes and general fitness athletes pursuing high power training concept.This was the very first predecessor of Rugenix. Further improvement of the Amino-BHT formula embraced attempts for reducing the time of immediate post-work restorative super-compensation effect. Yet, it required another decade of extensive research and in field trials to complete the task of creating the unique ion-bonded formula. Rugenix is protected first by Provisional then by full Utility Patents
The link between the alpha-ketoglutaric acid metabolic cycle and catabolic conditions in actively contracting skeletal muscle has been known since the early 1990’s. The particular role of dietary supplemented glutamine and its natural derivatives in arresting the process of muscle protein waste caused by stress has been epitomized (Wusteman et al., 1995; Vaubourdolle et al.,1991; Roth et al., 1990; Furst et al., 1990). These observations have also highlighted to the unique biological properties of glutamine, compared to other amino acids, i.e., its abundance in the body (plasma, skeletal muscle, liver, kidney, intestines), its intra-cellular presence in quantitative amounts, its role in the reactions of nitrogen and carbon transport among tissues, and its importance as a primary oxidative fuel in rapidly dividing intestinal and stimulated lymphocytes, as well as oxidative fuel and essential structural element for growing (undergoing hypertrophy) cells. Glutamine administered to human subjects as amino bio-heterodimer Glycylglutamine resulted in rapid and significant increase in the arterial concentration of glycine and glutamine, with less than 1 % of the infused amino-heterodimer recovered into urine.
Futhermore, Alanyl-Glutamin, Alanyl alpha-Ketoglutarate, and Ornithine alpha-Ketoglutarate have been shown to moderate consistently the degree of negative nitrogen balance, effectively increased the intramuscular concentration of free glutamine, and maintained the concentration of the ribosomes in skeletal muscle in distressed (hypercatabolic) patients. It was concluded then that feeding amino acid glutamine or its derivative alpha-ketoglutarate as C-terminal located residue in an amino bio-heterodimer, results in increased protein synthesis in the body (Lochs and Hubl, 1990). In other clinical studies it was shown that glutamine and its derivatives do elevate plasma glutamine without changing the ammonia concentration gradient (Shils, 1994).
Creatine is another natural amino acid derivative in the body with superior anabolic impact on skeletal muscle metabolism and of other organs and tissues whose viability under any extreme catabolic stress conditions had acquired the most popularity in sports practice for its unique promoting effect on protein synthesis in growing muscle cells (Silber, 1998; Silber et al., 1975; lngwall et al.,1972) which actually reflects the activation of the transcribed and translated determinants for natural and safe skeletal muscle growth, strength, and power generation (Silber, 1998; Kreider et al., 1998; Odland et al., 1997; Greenhaff et al., 1993; Harris et al., 1992). As a nutrition supplement, Creatine is currently available in the monohydrate form combined after HPLC. This form, when used in elevated doses, higher than 2 g per day, often causes adverse reaction in the digestive tract, which considerably reduces the expected benefits from its absorbance.
Lately, an extended list of amino bio-dimers, trimers, and oligomers have been reported for their increased tolerance, solubility, and stability during ingestion, compared to their free amino acid constituents (Shils, 1994; Abidi, 1987). Also, amino bio-heterotrimers of Ornithine conjugated with alpha-Ketoglutarate have been shown to produce anabolic and performance enhancing effects in animal and human trials (Raul et al., 1995; Hatfield, 1994; Vaubordolle. et al., 1991). Relying on this evidence Dr. Moris Silber firstly claimed that Creatine alpha-Ketoglutarate can be produced via chemical organic synthesis and have the following molecular structure. Secondly, he claimed that the newly configured product of Creatine alpha-Ketoglutarate will demonstrate superior biological activity and physiological effects on skeletal muscle growth, strength, and power generation capacity, compared with its individual constituents, Creatine and alpha-Ketoglutaric acid, in elite force/velocity athletes and general fitness athletes pursuing high power training concept.This was the very first predecessor of Rugenix. Further improvement of the Amino-BHT formula embraced attempts for reducing the time of immediate post-work restorative super-compensation effect. Yet, it required another decade of extensive research and in field trials to complete the task of creating the unique ion-bonded formula. Rugenix is protected first by Provisional then by full Utility Patents
